Ornithine-Crosslinked Sodium Hyaluronate

**Product Name:** Ornithine-Crosslinked Sodium Hyaluronate  

 **Description**  

Ornithine-Crosslinked Sodium Hyaluronate is a chemically modified form of sodium hyaluronate (hyaluronic acid) where ornithine, a non-proteinogenic amino acid, is used as a crosslinking agent. This modification enhances the stability, viscosity, and longevity of the hyaluronic acid matrix, making it suitable for advanced biomedical and cosmetic applications.

 **Structure**  

The product consists of hyaluronic acid chains crosslinked via ornithine molecules, forming a robust three-dimensional network. The crosslinking process improves resistance to enzymatic degradation (e.g., by hyaluronidase) and extends the material's functional lifespan in vivo.

**Properties**  

- **Appearance:** White to off-white powder or gel  

- **Solubility:** Soluble in water, forming a viscous solution  

- **pH:** 6.0–7.5 (1% aqueous solution)  

- **Viscosity:** High, depending on the degree of crosslinking  

- **Biocompatibility:** Excellent, suitable for dermal and subcutaneous applications  

- **Degradation:** Controlled degradation profile, resistant to enzymatic breakdown  

 **Applications**  

1. **Dermal Fillers:** Used in aesthetic medicine for skin augmentation, wrinkle reduction, and volume restoration.  

2. **Wound Healing:** Promotes tissue regeneration and hydration in wound care products.  

3. **Drug Delivery:** Acts as a carrier for sustained-release formulations.  

4. **Ophthalmic Solutions:** Provides lubrication and viscoelasticity in eye drops and surgical aids.  

5. **Cosmetic Formulations:** Enhances moisturization and anti-aging properties in skincare products.  

**Advantages**  

- **Enhanced Stability:** Improved resistance to enzymatic and thermal degradation.  

- **Long-Lasting Effects:** Prolonged duration of action compared to non-crosslinked hyaluronic acid.  

- **Biodegradable:** Safely metabolized in the body.  

- **Versatile:** Compatible with a wide range of formulations and applications.  

 **Safety and Handling**  

- **Storage:** Store in a cool, dry place at 2–8°C. Protect from light and moisture.  

- **Handling:** Use appropriate personal protective equipment (PPE) when handling. Avoid inhalation or contact with eyes and skin.  

- **Sterility:** Ensure sterile conditions for biomedical applications.  

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For further information, please contact [Insert Manufacturer/Supplier Contact Information].  

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**Disclaimer:** This document is for informational purposes only. Always refer to the product's technical data sheet and safety guidelines before use.